Bio-Resveratrol^™

Dr. Ivan Mikhailovich Petyaev, MD, PhD

Dr. Ivan Petyaev is a medical doctor, practicing cardiologist, researcher and inventor of new technologies for pharmaceutical, nutraceuticals, functional food, personalized diagnostics and cosmetic industries.

Ivan has wide experience in driving his discoveries and inventions from lab and clinical product developments to the market. He is the CEO of Lycotec Ltd. and the inventor of the Carocelle™ process for enhancing bioavailability of orally delivered drugs and nutritional bioactives. The Carocelle™ process has demonstrated the ability to create highly differentiated nutraceuticals with the highest bioavailability – lycopene for cardiovascular health, lutein-zeaxanthin for cognition and retina health, and resveratrol for regeneration and cell protection.

Dr. Petyaev’s projects have at different times been supported by Cambridge University, the British Heart Foundation and the Department of Trade and Industry.

Lycotec was ranked at the highest tier of best European Innovation Companies by Eureka’s Eurostars Programme.

Recently its oral delivery technology received Award at the World Liver Targeting Conference for its value and potential.

Carocelle™ delivery technology provides superior clinically validated bioavailability and bio efficacy of a spectrum of key nutrients. It is a patented Micelles Formation Technology – licenced from: Lycotec, Cambridge, UK, a company established by Cambridge University scientists including Dr. Ivan Petyaev, MD, PhD.

Lycopene and lutein are fat-soluble molecules; they will not dissolve in water. For our bodies to use fat-soluble nutrients like lycopene, or vitamin A, D, E or K, it needs to surround them in a structure that can act like an emulsifier to make it “dissolve”—much like soap can dissolve oils from dirty dishes.

Our bodies have a process for making these fat-soluble nutrients absorbable. First, the liver forms bile acids and then conjugates them to form bile salts, which the gall bladder secretes. These bile salts surround molecules of lipids and other fat-soluble nutrients forming a water-soluble micelle molecule containing the fat-soluble nutrient “cargo” in its center. These micelles can then be absorbed by the small intestine.

Forming micelles takes time and requires ample amounts of bile salts. Until the micelle structures are formed, the fat-soluble nutrients like lycopene and lutein are subject to damage from the stomach acids.
Resveratrol has very low solubility in water, which affects our bodies abilities to absorb it. Once resveratrol is ingested (either with food or as a supplement) it is subject to oxidation (since it is a powerful antioxidant) and breakdown by intestinal enzymes.

Resveratrol also has extremely low bioavailability—one study suggests approximately 0.5% of ingested resveratrol actually enters the bloodstream in “unchanged” form.

MedVitál lutein, lycopene and resveratrol products use the patented Carocelle® delivery system developed by Dr. Ivan Petyaev, MD, PhD. to encase the nutraceutical “cargo” in a pre-made micelle structure. The Carocelle process is the result of 10 years of research at Cambridge University and its spin-off biotech company, Lycotec Ltc. By using pre-formed micelles, the body does not have to wait for bile salts to form, be secreted and form micelles in the stomach before the body can begin absorbing the lycopene. As a result, MedVital Bio-Lycopene achieves superior bioavailability.

In studies by Lycotec, the Carocelle process showed superior bioavailability in blood levels far greater than any other delivery method tested.