What is Cinnulin PF®?
Cinnulin PF® is the patented and clinically studied water–soluble extract of cinnamon containing Type-A Polymers. Cinnulin PF is extracted from the Cinnamomumburmannii species and unlike raw cinnamon powder does not contain coumarin or other undesirable components. Cinnulin PF has been shown to support healthy blood sugar metabolism.+
Cinnamon has remained one of the world’s most popular and widely used spices throughout recorded history. Usage of cinnamon in Chinese medicine is said to date back over 4,000 years. Cinnamon was imported to Egypt and Europe from the Far East by 500 B.C. In addition to its value as a culinary spice, cinnamon has traditionally been utilized for immune health and supporting digestive function.
Researchers at the U.S. Department of Agriculture (USDA) have discovered that constituents in cinnamon bark called procyanidin Type-A polymers are the bioactive phytonutrients that help maintain the body’s ability to metabolize glucose in a healthy way.* Cinnulin PF®, is a clinically-studied, patented water extract of cinnamon that contains these Type-A polymers.
The proprietary extraction process helps filter out the toxic compounds typically found in whole cinnamon. It is the only commercially available extract standardized for doubly linked Type-A Polymers, specifically tetramers and trimers shown in clinical research to have a host of health benefits.
+These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Health Benefits of Cinnulin PF
Cinnulin PF® shows strong potential health benefits in the areas of:
- Helping to maintain healthy blood sugar levels
- Lowering body fat/enhancing lean body mass
- Helping to maintain blood pressure within normal range
Cinnulin PF is the only extract standardized for doubly linked Type-A Polymers, specifically tetramers and trimers shown in clinical research to have a host of health benefits, particularly those related to metabolism.+
In a recent study, 83% of those given the active Type A Polymers experienced a significant decrease in fasting blood sugar (about an 8% drop), compared to only 33% in the placebo group.1
Cinnulin PF was tested in a 12 week, randomized, double blind, placebo-controlled clinical trial with pre-diabetic men and women with features of metabolic syndrome. Cinnulin PF or a placebo was taken at a dosage of 500mg per day. Cinnulin PF, versus the placebo, demonstrated significant improvements in fasting blood sugar, systolic blood pressure and showed and increase in lean body mass, a reduction in body fat, and saw improvements in various antioxidant measures.*
The Science behind Cinnulin PF®
Helping to Maintain Healthy Blood Sugar Levels+
Ongoing research is revealing the health properties of cinnamon beyond its use as a spice in healthy diets around the world. The research has been able to identify three areas where cinnamon, and especially Cinnulin PF, can help to:
- Maintaining healthy glucose and insulin levels
- Maintaining a healthy metabolism
- Enhance overall health
The diagram below details how Cinnulin PF has a dual-action to help the body to maintain healthy glucose levels.
Maintaining Healthy Glucose and Insulin Levels
Expanding waistlines are not just a source of frustration for many aging adults trying to retain a youthful appearance. It is often the sign of a more insidious process that threatens to undermine long-term health.
Once thought to just to be a compartment for storing excess energy, body fat is now seen as a highly metabolic organ—especially body fat that accumulates around the waist called abdominal adiposity.
When the body senses it has reached a limit of how much excess energy it can store, the adipose tissue releases compounds called adipokines and cytokines that interfere with the body’s ability to shuttle any more glucose into the cells.2 Free fatty acids in the bloodstream, a condition often present in tandem with excess body weight, can inhibit glucose uptake into cells.3 This reduced ability to shuttle glucose into cells when the cell is activated by insulin at its insulin receptors, is called insulin resistance.
As shown in the diagram, if insulin resistance is allowed to persist unabated, it can progress into a chronic state of elevated glucose in the blood (hyperglycemia) state called prediabetes. Typically lifestyle changes can reverse this progression. If allowed to progress further, it can evolve into Type 2 diabetes.
Based upon these statistics from the National Diabetes Statistics Report, 2014, the number of people progressing from insulin resistance to prediabetes and beyond is alarmingly high. According to the American Podiatric Medical Association close to 25% of the US population has prediabetes.
Adding to this burgeoning statistic is that the classification for prediabetes has been lowered the fasting glucose limits from 110 mg/DL to 100 mg/DL. Fasting plasma glucose test measures blood glucose in people who have not eaten anything for at least 8 hours.
Source: Adapted from American Diabetes Association. Standards of medical care in diabetes—2012. Diabetes Care. 2012;35(Supp 1):S12, table 2.
A report in one of the American Diabetes Association’s own journals found that fasting glucose levels above 85 mg/DL (upper normal range) in “nondiabetic apparently healthy middle-aged men” was a primary predictor of cardiovascular health. This was true regardless of exercise and cholesterol levels, in smokers and non-smokers alike.4
Aging non-diabetic individuals typically have fasting glucose readings far above 90 mg/DL. By using Cinnulin PF, along with a sensible diet and exercise, one may be able to reduce fasting glucose to healthy levels within the normal range.
Insulin Resistance Discovery: PTP-1B
Researchers reached a milestone in understanding the complexity in insulin signaling at the cellular level that is perpetuating insulin resistance, especially from obesity. It is as if there is glucose in the bloodstream but the cell is blinded to its presence. It seems that protein tyrosine phosphatase (PTP-1B for short) can prevent the activation of insulin at the cellular receptor sites, inhibiting the cell’s response to allow glucose to move from the bloodstream into the cells.5
An earlier discovery showed that bioactive compounds found in cinnamon can inhibit PTP-1B that is responsible for inactivating the insulin receptor.6, 7
Selling Notes:
- Bioactive compounds in cinnamon help to restore the cell’s ability to sense the availability of glucose in circulation. By inhibiting PTP-1B, insulin is able to initiate a chain reaction in the cell that allows glucose to flow freely into the cell to provide it the critical energy it needs to survive.
- By maintaining insulin’s normal action at the cellular level, glucose ismoved from circulation into the cells so the body is not in a state of hyperglycemia.
Why Cinnulin PF® Matters
Why Cinnulin PF is the first and best choice for cinnamon
The popularity of the use of cinnamon bark as a therapeutic intervention for a number of health concerns has exploded over the last decade due to extensive media coverage from companies and health advocates that want to enlighten consumers to the health benefits of a wonder spice sitting in their cupboard, cinnamon.
More is not Better
Consumers consider spices like cinnamon, turmeric, rosemary, etc. as “consumer friendly” as they are accustomed to using it as a food ingredient. The typical “more is better” mindset is that if it is a healthy food with hidden health benefits, then it can’t hurt. If the spice is used traditionally in health and longevity diets around the world, then it has appeal is even greater appeal and acceptance as Americans seek diets that can have a positive impact on their health.
The “natural” halo of spices can be deceiving though. Most spices are manufactured and sold as flavor enhancers for food and not intended to be used at high doses. As plants, spices often have an array of healthy phytonutrients but plants can also contain toxic chemicals used as natural defenses to protect themselves from environmental challenges. Consumed at low levels, these toxic phytochemicals are typically not a health hazard.
That is not the case for cinnamon. Cinnamon is such a widely used spice in food preparation and processed foods, that Americans are often consuming excessive levels of these undesirable chemicals including a natural form of the blood-thinner coumadin already, and it may be having an unseen negative impact on their health.10Even though the various species of cinnamon are classified as GRAS (generally regarded as safe for use as a food additive), GRAS sets limits to ensure safety.
Safety F1RST
The water-soluble cinnamon extract, Cinnulin PF®, addresses this critical safety concern. Cinnulin PF, a as nutraceutical intervention needs to be consumed daily at higher doses in order to be effective. So the cinnamon raw material needed to be extracted in such a way to retain its healthy-giving phytonutrients while leaving behind the toxic compounds. Cinnulin PF is the result of that innovation. It is a water-soluble extraction that leaves behind the lipid-soluble components of cinnamon that are most likely to be toxic when the spice is used at high doses for extended periods of time.11
Selling Note:
- If the cinnamon the customer is using or plans to buy is not the patented aqueous extract, it could have high levels of lipid (fat) soluble toxic compounds, such as coumarins, that have raised safety concerns in the United States and Europe when large amounts of cinnamon are ingested frequently for health promotion purposes.
Maintenance of Healthy& Body Weight
More than 9% of the US population has been diagnosed with diabetes, with the vast majority as adult-onset Type II diabetes that can be managed with diet, exercise, medical treatment and supplements. According the the U.S. Centers for Disease Control website: http://www.cdc.gov/diabetes/prevention/prediabetes.htm, one out of three Americans is prediabetic. Not only are they struggling with maintaining a healthy blood sugar level; they may also be struggling with maintaining a healthy weight.
According to the report, “Prevalence of Overweight, Obesity, and Extreme Obesity Among Adults: United States, Trends 1960–1962 Through 2009–2010” released by the Centers for Disease Control and Prevention, obesity is on the rise for both men and women.
Fat cells produce chemicals that inhibit glucose uptake into cells (via PTP-1B activation), creating a state of hyperglycemia, and also catalyze glycation reactions that accelerate structural aging of the body.
Cinnulin PF is a tool to assist in maintaining healthy blood sugar.+
Patents
Considerable amount of time, effort and expense has been invested by the patent owners to protect safe, effective Cinnulin PF from copycat ingredients that use “borrowed science” that have entered the market. Often patents are either protecting the composition as unique or the use as unique such as treating a health condition. This patent protects both.
Cinnulin PF is covered by US patent #6,200,569 – Water extract or a dilute acidic extract of polygonum multiform roots or cinnamomum bark; decreasing the glycosylated hemoglobin level or blood glucose level in a hyperglycemic patient.
Cinnulin PF® is a registered trademark of Integrity Nutraceuticals International and is manufactured under US Patent # 7,504,118; 8,300,141; 8,318,221.
Appendix A: References
- Ziegenfuss TN, Hofheins JE, Mendel RW et al. Effects of a water-soluble cinnamon extract on body composition and features of the metabolic syndrome in pre-diabetic men and women.J IntSoc Sports Nutr. 2006;3:45-53. doi: 10.1186/1550-2783-3-2-45.
- Zabolotny JM, Kim YB, Welsh LA, Kershaw EE, Neel BG, Kahn BB. Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo. Journal of Biological Chemistry (Impact Factor: 4.65). 06/2008; 283(21):14230-41
- Roden M, Price TB, Perseghin G, Petersen KF, Rothman DL, Cline GW, Shulman GI. Mechanism of Free Fatty Acid-Induced Insulin Resistance in Humans. J Clin Invest. Jun 15,1996; 97(12):2859-2865.
- Bjørnholt JV, Erikssen G, Aaser E, Sandvik L, Nitter-Hauge S, Jervell J, Erikssen J, ThaulowEDiabetes Care.Fasting blood glucose: an underestimated risk factor for cardiovascular death. Results from a 22-year follow-up of healthy nondiabetic men. Diabetes Care. 1999 Jan;22(1):45-9.
- Xu E, Schwab M, Marette A.Role of protein tyrosine phosphatases in the modulation of insulin signaling and their implication in the pathogenesis of obesity-linked insulin resistance.Rev EndocrMetabDisord. 2014 Mar;15(1):79-97.
- Imparl-Radosevich J, Deas S, Polansky MM, Baedke DA, Ingebritsen TS, Anderson RA, Graves DJHorm Res.Regulation of PTP-1 and insulin receptor kinase by fractions from cinnamon: implications for cinnamon regulation of insulin signaling.1998 Sep;50(3):177-82.
- Qin B1, Nagasaki M, Ren M, Bajotto G, Oshida Y, Sato Y. Cinnamon extract (traditional herb) potentiates in vivo insulin-regulated glucose utilization via enhancing insulin signaling in rats. Diabetes Res ClinPract. 2003 Dec;62(3):139-48.
- Peng X, Cheng K-A, Ma J, Chen B, Ho C-T, Lo C, Chen F, Wang M. Cinnamon bark proanthocyanidins as reactive carbonyl scavengers to prevent the formation of advanced glycationendproducts. J Agric. Food Chem., 2008, 56(6):1907-1911.
- Cgen S, Chang P-W. Inhibitory effects of several spices on inflammation caused by advenacedglycationendproducts.Am. Journal Plant Sciences, 2012, 995-1002.
- Yan-Hong Wang, BharathiAvula, N. P. DhammikaNanayakkara, Jianping Zhao, and Ikhlas A. Khan. Cassia Cinnamon as a Source of Coumarin in Cinnamon-Flavored Food and Food Supplements in the United States.J. Agric. Food Chem., 2013, 61 (18), pp 4470–4476.
- Anderson RA, Broadhurst CL, Polansky MM, Schmidt WF, Khan A, Flanagan VP, Schoene NW, Graves DJ.Isolation and characterization of polyphenol type-A polymers from cinnamon with insulin-like biological activity.J Agric Food Chem. 2004 Jan 14;52(1):65-70.
- Ruike T, Leong DJ, Grosjean F, Esposito V, MAjeska RJ, Iatridis JC, Vlassara H, Striker GE, Sun HB. Accumulation of advanced glycationendproducts induces cartilage degradation via Activation of Syndecan-4-ADAMTS-5 pathway. ORS annual Meeting.Poster No. 0701
