Name: pTeroPure<sup>™</sup>
SKU: 65500032
Availability: OutOfStock

What is pTeroPure™?

F1rst pTeroPure™ is the patented and clinically studied >99% pure form of the all-trans pterostilbene (pronounced “tero STILL bean”), a highly bioavailable form of double-methylated resveratrol found in blueberries that is more easily absorbed by the cell and has a longer half-life in the body compared to trans-resveratrol.* Pterostilbene is in the same chemical family as resveratrol and is found in minute quantities in grapes (Vitis vinifera) and blueberries (Vaccinium spp). Pterostilbene acts as an antioxidant, and promotes cellular and heart health.* pTeroPure™ is safe for everyday use.

What Does It Do?

A Superior Resveratrol

pTeroPure™ offers several significant advantages over resveratrol. It is more available to our bodies: about 80% bioavailability compared to about 20% for trans-resveratrol in animal models. It also lasts much longer in our bodies, seven times longer in animal models. Moreover, pTeroPure™ has greater oral absorption and metabolic stability than resveratrol. Research suggests that pTeroPure™ pterostilbene’s antioxidant and cellular metabolism effects may benefit heart health.*

Research suggests that pTeroPure™ may have the following key benefits:

Heart Health, by helping to maintain healthy systolic and diastolic blood pressure levels already within normal ranges.*
Cellular anti-aging antioxidant, helping to fight free radicals caused by oxidative stress and support healthy cellular aging *
A superior form of resveratrol, with greater bioavailability and a longer half-life in the body.

Why pTeroPure™ Matters

Patented pure (>99%) form pure form of the all-trans Pterostilbene (tero STILL bean) found naturally in blueberries.
A better resveratrol, with significant advantages over resveratrol:
- Superior bioavailability
- Longer half-life in the body
- Greater oral absorption & metabolic stability
- Greater cellular uptake
Helps to maintain healthy systolic and diastolic blood pressure levels already within normal ranges.*
Cellular anti-aging antioxidant, helping to fight free radicals caused by oxidative stress and support healthy cellular aging *
Non-stimulant
Seven patents issued or pending.
Multiple gold-standard clinical trials in humans and animals.
Vegetarian capsules for ready availability

Product Details

F1rst pTeroPure™is the patented and clinically studied pure form of the all-trans Pterostilbene (tero STILL bean) found naturally in blueberries. Pterostilbene is known to act as an antioxidant, promotes cellular health and is better absorbed and has a longer half-life in the body than resveratrol.*

SUGGESTED USE: As a dietary supplement, one capsule daily with a large glass of water. Suitable for vegetarians.

Warning: Consult your physician prior to taking this product if you are pregnant, nursing, taking medication or have a medical condition.

nutrition-pteropure

Other ingredients: Microcrystalline Cellulose, Magnesium Stearate (vegetable source), Hypromellose, Silicon Dioxide.

Allergen Warning: This product was produced in a facility that may also process ingredients containing milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, and soybeans.

Borrowing health defenses from plants.

Environmentally stressed plants produce bioactive compounds for their own defense. Some of these compounds can also confer benefits in humans. Carefully stressing plants in specific ways can increase the yield of these health-promoting plant compounds. These plant compounds can, when ingested, pass along the health benefits.

Direct Modulation of Key Mammalian Enzymes by Plant Metabolites

Several plant compounds in our diet interact with key regulators of mammalian physiology to provide health benefits. Shown below are four examples: pterostilbene found in blueberries; resveratrol found in numerous plants and concentrated in red wine; curcumin from turmeric; and epigallocatechin-3-gallate (EGCG) in green tea. These compounds modulate key pathways that influence cellular health. Some interactions activate signaling pathways (arrows) whereas others inhibit them (bars). Solid arrows or bars indicate instances where there is some evidence of a direct interaction of the plant metabolite with a mammalian protein.

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Pterostilbene – Supporting cellular health!

Novel polyphenols like stilbenes (pterostilbene, resveratrol), when ingested, can have a number of actions on various cellular pathways that support cellular health. Pterostilbene, by virtue of its structure and metabolism, can serve as an antioxidant. Antioxidant actions can influence a variety of cellular events and be important in cellular response.

Pterostilbene may also act via Nrf2, a powerful protein that must be activated as part of a healthy response. Once released it migrates into the cell nucleus and binds to the DNA at the location of the Antioxidant Response Element (ARE) or also called hARE (Human Antioxidant Response Element) which is the master regulator of the total antioxidant system that is available in all human cells.

Activation of Nrf2 essentially opens the door for the production of a vast array our.

Next generation pterostilbene triggers the activation of this Nrf2-ARE pathway

pTeroPure® & ChromaDex Patents

ChromaDex holds exclusive worldwide manufacturing and use patents for pterostilbene based upon technology from the University of Mississippi and the USDA for conditions such as hearth health, memory improvement, neuroprotection.

Select Patents:

Cholesterol (University of Mississippi) – Issued
Oxidative stress and neuroprotection for cognitive function (University of Mississippi) – Pending
Mood and nervous system effects (University of Mississippi) – Pending
Manufacturing process (Laurus Labs) – Pending
Skin health (jointly with U.C. Irvine) – Pending
Heart health- Pending

Appendix A: References

Hooper PL, Hooper PL, Tytell M, Vigh L. Xenohormesis: health benefits from an eon of plant stress response evolution. Cell Stress and Chaperones. June 2010.
Banchio et al. Systemic induction of monoterpene biosynthesis in Origanum x majoricum by soil bacteria. J Agric Food Chem. 2019;58;650-654.
Howitz KT, Sinclair DA. Xenohormesis: Sensing the chemical cues of other species. Cell. May 2 2008; 133(3):387-391.
Son TG, Camandola S, Mattson MP. Hormetic dietary ployphenols. Neuromolecular Med. 2008; 10(4):236-46.
Birringer M. Hormetics: Dietary triggers of an adaptive stress response. Pharm Res. 2011 Nov;28(11):2680-94.

Appendix B: Additional References

Riche DM, Deschamp D, Griswold ME, McEwen CL Riche KD, Sherman JJ, Wofford MR. Impact of pterostilbene on metabolic parameters in humans. Poster presentation at: American Heart Association 2012 Scientific Sessions , September 20, 2012.

Joseph JA, Fisher DR, Cheng V, Rimando AM, Shukitt-Hale B. Cellular and behavioral effects of stilbene resveratrol analogues: implications for reducing the deleterious effects of aging. Journal of Agricultural and Food Chemistry. 2008;56(22):10544–10551

Casadesus G, Shukitt-Hale B, Stellwagen HM, et al. Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats. Nutritional Neuroscience. 2004;7(5-6):309–316.

Grover JK, Vats V, Yadav SS. Pterocarpus marsupium extract (Vijayasar) prevented the alteration in metabolic patterns induced in the normal rat by feeding an adequate diet containing fructose as sole carbohydrate. Diabetes, Obesity and Metabolism. 2005;7(4):414–420

Satheesh MA, Pari L. The antioxidant role of pterostilbene in Wistar rats. Journal of Pharmacy and Pharmacology. 2006;58(11):1483–1490

Rimando AM, Cuendet M, Desmarchelier C, Mehta RG, Pezzuto JM, Duke SO.Antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol. Journal of Agricultural and Food Chemistry. 2002;50(12):3453–3457

Adly AAM. Oxidative stress: an updated review. Research Journal of Immunology. 2010;3(2):129–145

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